The potential of NMN supplementation first emerged through animal studies, where long-term administration led to improved metabolic health, enhanced energy balance, and extended healthspan in mice. NMN has been observed to enhance insulin sensitivity, reduce age-associated weight gain, and support mitochondrial function.

In humans, early-stage clinical studies provide encouraging signals. In a Japanese safety trial, oral NMN up to 500 mg was well tolerated among healthy adults, with no major adverse effects recorded. Slight adjustments in physiological markers remained within safe clinical ranges.

A separate investigation focusing on women over 55 years old demonstrated that regular NMN intake improved muscle insulin sensitivity — a crucial indicator of metabolic health. Better insulin sensitivity supports more efficient glucose uptake by muscles, aiding in energy regulation, physical endurance, and long-term metabolic wellness.

While large-scale human trials are still ongoing, these findings highlight NMN’s real biological activity and its potential role in promoting healthier aging processes.